Darryl Hood

Associate Professor of Environmental Health Sciences

Darryl Hood

College of Public Health
Email: dhood@cph.osu.edu
Website: http://cph.osu.edu/people/dhood
Topics: environment

Background

Darryl Hood recently joined the faculty of the College of Public Health from Meharry Medical College where he interrogated hypotheses on the mechanisms governing neurotoxicity of environmental chemicals for nearly two decades. Seminal work conducted in his laboratory demonstrated for the first time, the functional impact of in utero exposure to benzo(a)pyrene on later-life behavioral phenotypes mediated by maturing glutamatergic cortical circuits. From his work, the field has learned that postnatal brain development requires input from the environment in order to induce the release of glutamate and thereby promote critical aspects of synaptic maturation.

His most impactful paper demonstrated that it is during the process of postnatal synaptogenesis (P1-P14) that the effects of in utero B(a)P exposure on neural activity alter the temporal expression of glutamatergic genes. Moreover, his work also demonstrated that in utero exposure to benzo(a)pyrene for a restricted time period (E14-E17) is sufficient to generate long-term changes in key regulators of glutamatergic signaling after birth, which in conjunction with other molecular disruptions, manifest as behavioral deficit phenotypes. Overall, the collective body of work emanating from his laboratory has confirmed the notion that common environmental pollutants can have a direct, negative impact on the regulated developmental expression of key regulators of glutamatergic signaling with associated negative behavioral learning and memory outcomes. From a cumulative risk-assessment point of view, data from Dr. Hood’s laboratory has contributed to the database that addresses why low income and medically underserved populations that work, reside, attend school, and play in environmentally contaminated neighborhoods have disproportionate, adverse cognitive health outcomes. In the CPH, Dr. Hood plans to capitalize on research findings and resources from NIEHS-supported epidemiological and clinical studies towards defining new exposure-induced susceptibility endophenotypes in models that reflect adverse pregnancy outcomes.

Research Interests

Inhalation Toxicology (prenatal exposure models autism)

Developmental neurobiology (somatosensory cortex)

Behavioral neurobiology (development of structure-specific paradigms)

Environmental and biochemical toxicology (Nitroxides, PAH’s)

Dispersion modeling of PAH’s in environmental justice communities

Structural biology, protein structure and function

Environmental-exposure health assessment questionnaire development

Modeling exposures across lifetime using public health exposome approach

Education

Postdoc, Vanderbilt University School of Medicine, Dept. of Biochemistry and Center in Molecular Toxicology, Biophysics/ Molecular Toxicology, 1990-1994

Ph.D., East Tennessee State University, James H. Quillen College of Medicine, Biomedical Science/Biochemistry, 1990

B.S., Johnson C. Smith University, Biology/Chemistry, 1985

Selected Publications

Chen CK, Bruce M, Tyler L, Brown C, Garrett A, Goggins S, Lewis-Polite B, Weriwoh ML, Juarez PD, Skelton T, Hood DB. (2013) Analysis of an environmental exposure health questionnaire in a metropolitan minority population utilizing logistic regression and support vector machines. J Health Care Poor Underserved. Feb; 24 (1 Suppl):153-171. doi: 10.1353/hpu.2013.0046. PMID: 23395953

Robinson PL, Dominguez F, Teklehaimanot S, Lee M, Brown A, Goodchild M, Hood DB. (2013) Does distance decay modeling of supermarket accessibility predict fruit and vegetable intake by individuals in a large metropolitan area? J Health Care Poor Underserved. Feb; 24 (1 Suppl):172-185. doi: 10.1353/hpu.2013.0049.PMID: 23395954

Mejia de Grubb MC, Kilbourne B, Kihlberg C, Levine RS, Hood DB. (2013) Demographic and geographic variations in breast cancer mortality among U.S.hispanics. J Health Care Poor Underserved. Feb; 24 (1 Suppl):140-152. doi: 10.1353/hpu.2013.0043. PMID: 23395952

Rehr R, Wilson S, Hood DB. (2013) The Maryland commission on environmental justice and sustainable communities: a review. J Health Care Poor Underserved. Feb; 24 (1 Suppl):129-139. doi: 10.1353/hpu.2013.0040. PMID: 23395951

Developing a cadre of transdisciplinary health disparities researchers for the 21st Century. Matthews-Juarez P, Jack L, Kennedy K, Hood DB. (2013) J Health Care Poor Underserved. Feb; 24(1 Suppl):121-128. doi: 10.1353/hpu.2013.0037. PMID: 23395950

Juarez P, Hood DB. Sequencing the public health genome. (2013) J Health Care Poor Underserved. Feb; 24(1 Suppl):114-20. doi: 10.1353/hpu.2013.0035. PMID: 23395949

Diggs D, Myers J, Banks LD, Hood DB, Roberts LJ, Ramesh A. (2013) Influence of dietary fat on benzo(a)pyrene biotransformation in a B(a)P-induced mouse model of colon cancer. Journal of Nutritional Biochemistry (in press)

Juarez PD., Hood DB, Im W, Levine RS, Matthews-Juarez P, Agboto V, Al-Hamdan M, Crosson WL, Estes MG, Estes S, Kilbourne B, Langston ML, Lichtveld M, Robinson P, Samaniego V, Woods C, Kilbourne K, Skelton T (2013) The Public Health Exposome: A Health Disparities Exposure Science Paradigm. American Journal of Public Health (in review)

Agboto VK; Langston ML; Juarez P; Matthews-Juarez P; Hood DB; Ding Tan; Rust GD, Maboudou-Tchao E, Kilbourne B; Sanderson M; Pisu M, Levine RS. (2013) A method for systematic community selection in evaluating breast cancer interventions: The use of mortality data. American Journal of Epidemiology (in review)

McCallister MM, Jules GE, Maguire M, Ramesh A, Newland MC, Hood DB. (2013) Identification and characterization of later-life spatial discrimination deficits subsequent to in utero exposure to benzo(a)pyrene aerosol. Toxicol. Sci. (in review)


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