Study in mice suggests that when fathers exercise, their offspring are healthier
The Ohio State University
A new study in animals suggests that paternal exercise might have significant impact on the health of offspring – even into adulthood.
Researchers used a mouse model to investigate how a father’s exercise regimen would affect his offspring’s metabolic health.
They fed male mice either a normal diet or a high-fat diet for three weeks. Some mice from each diet group were sedentary and some exercised freely. After three weeks, the mice bred and their offspring ate a normal diet under sedentary conditions for a year.
The researchers reported on Oct. 22 in the journal Diabetes that adult offspring from sires who exercised had improved glucose metabolism, decreased body weight and a decreased fat mass.
“Here’s what’s really interesting: Offspring from the dads fed a high-fat diet fared worse, so they were more glucose intolerant. But exercise negated that effect,” said study leader Kristin Stanford, a physiology and cell biology researcher with The Ohio State University College of Medicine at the Wexner Medical Center.
“When the dad exercised, even on a high-fat diet, we saw improved metabolic health in their adult offspring.”
Laurie Goodyear of the Joslin Diabetes Center and Harvard Medical School co-led the study.
“This work is an important step in learning about metabolic disease and prevention at the cellular level,” said Dr. K. Craig Kent, dean of the Ohio State College of Medicine.
Recent studies have linked development of type 2 diabetes and impaired metabolic health to the parents’ poor diet, and there is increasing evidence that fathers play an important role in obesity and metabolic programming of their offspring.
In this new work, Stanford’s team also found that exercise caused changes in the genetic expression of the father’s sperm that suppress poor dietary effects and transfer to the offspring.
“We saw a strong change in their small-RNA profile. Now we want to see exactly which small-RNAs are responsible for these metabolic improvements, where it’s happening in the offspring and why,” said Stanford, a member of Ohio State’s Diabetes and Metabolism Research Center.
Previous studies from this group have shown that when mouse mothers exercise, their offspring also have beneficial effects of metabolism.
“There’s potential for this to translate to humans. We know that in adult men obesity impairs testosterone levels, sperm number and motility, and it decreases the number of live births,” Stanford said. “If we ask someone who’s getting ready to have a child to exercise moderately, even for a month before conception, that could have a strong effect on the health of their sperm and the long-term metabolic health of their children.”
(Video via ABC6/Courtesy: CNN Newsource)
The researchers believe the results support the hypothesis that small RNAs could help transmit parental environmental information to the next generation.
“Based on both studies, we’re now determining if both parents exercising has even greater effects to improve metabolism and overall health of offspring. If translated to humans, this would be hugely important for the health of the next generation,” Goodyear said.
Other Ohio State researchers involved in the study were Lisa Baer, Adam Lehnig and Joseph White.
Funding from the National Institutes of Health supported this research.